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Pediatric Brain Tumor Program
St. Jude Cloud
Data Resource:  St. Jude Cloud
Point of Contact:  
Clay McLeod ; Jinghui Zhang,  
Project

About This Dataset
The Pediatric Brain Tumor Portal (PBTP) is organized by the St. Jude Children's Research Hospital Neurobiology and Brain Tumor Program. Investigators have access to specialized resources, such as an integrated support structure for preclinical modeling, including patient-derived xenograft samples. The program consists of clinicians, radiation oncologists, neurobiologists, medicinal chemists, and other research faculty and staff. PBTP features molecular characterization for patient-derived orthotopic xenograft (PDOX) models of pediatric CNS tumors and reflects close to 10 years of effort to generate and extensively characterize in vivo models that faithfully recapitulate pediatric brain cancer diseases. The portal offers visualization tools that allow users to interrogate curated datasets and access models from our library of PDOX for functional studies of tumorigenesis or preclinical testing.
Core Data Elements
Number of Cases
55
Case Sex
Female (18); Male (37)
Case Age At Diagnosis
0 to 4 years (16); 5 to 9 years (17); 10 to 14 years (14); 15 to 19 years (8); Pediatric and Young Adult (<40 years) (1)
Case Race
Black or African American (3); White (15); Not Reported (37)
Case Ethnicity
Hispanic or Latino (2); Not Hispanic or Latino (16); Not Reported (37)
Case Disease Diagnosis
Atypical Teratoid/Rhabdoid Tumor, MYC subgroup (3); Atypical Teratoid/Rhabdoid Tumor, SHH subgroup (2); Atypical Teratoid/Rhabdoid Tumor, TYR subgroup (1); Diffuse Intrinsic Pontine Glioma; High-Grade Glioma, NOS (1); Embryonal Tumor with Multilayered Rosettes, Brain (1); Ependymomal Tumor, Posterior Fossa (2); Ependymomal Tumor, Supratentorial (1); Ependymomal Tumor; Ependymomal Tumor, Posterior Fossa (2); Glioblastoma (1); High-Grade Glioma, NOS (16); High-Grade Glioma, NOS; Medulloblastoma (1); High-Grade Glioma, NOS; Pleomorphic Xanthoastrocytoma (1); Medulloblastoma, Group 3 (3); Medulloblastoma, Group 3; Medulloblastoma (1); Medulloblastoma, Group 4 (5); Medulloblastoma, Group 4; Medulloblastoma (2); Medulloblastoma, SHH subtype (6); Medulloblastoma, SHH subtype; Wilms (1); Medulloblastoma, WNT subtype (3)
Case Tumor Site
Not Reported (55)
Number of Samples
199
Sample Assay Method
RNA Sequencing (64); Whole Exome Sequencing (70); Whole Genome Sequencing (65)
Sample Is Xenograft
Yes (155)
Additional Data Elements
DATA REPOSITORY
Grant Information
P01CA096832
Normal & Neoplastic Growth in the Brain
P30CA021765
Cancer Center Support Grant (CCSG)
R01CA232143
Dissecting the Spectrum, Prevalence, and Molecular Mechanisms of Enhancer Hijacking in Medulloblastoma
Published In
https://doi.org/10.1007/s00401-020-02171-5
SAMPLE TYPE
Autopsy (6);  
Cell Line (10);  
Diagnosis (17);  
Germline (11);  
Xenograft (155);  
Charts
Male (37); Female (18)
37Male